Across TCGA cell cohorts, HMX2 mutation is significantly associated with the RNA expression of many other genes, with 552 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMX2-associated genes across cancer lineages are CBY1, FZD3, and TRIM37. Each is linked with HMX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMX2-to-partner and partner-to-HMX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMX2→partner) and Y-score (partner→HMX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.744	+3.299	<.001	.004	3	1
LARGE_INTESTINE	FZD3 →	+0.860	+3.212	.001	.006	3	1
LARGE_INTESTINE	TRIM37 →	+0.772	+3.212	<.001	.006	3	1
LARGE_INTESTINE	UNC119 →	+0.774	+3.299	.001	.004	3	1
LARGE_INTESTINE	USP46 →	+0.831	+3.299	<.001	.004	3	1
LARGE_INTESTINE	MANBA →	+0.982	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 552 associations by consensus.

Exploration

HMX2 survival (RNA) · tumor vs normal (RNA) · all HMX2 data types