Across TCGA patient cohorts, HMSD RNA expression is significantly associated with the protein abundance of many other proteins, with 9,266 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HMSD-associated proteins across cancer lineages are SPN, YWHAB, and ACAP1. Each is linked with HMSD in more than 3 cancer types. Because this analysis shows association rather than direction, both HMSD-to-partner and partner-to-HMSD results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMSD→partner) and Y-score (partner→HMSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPN →	+0.504	+0.324	<.001	<.001	3	4
COAD	YWHAB →	-0.432	-0.746	<.001	<.001	3	4
BRCA	ACAP1 →	+0.624	+0.321	<.001	<.001	3	4
HNSC	CDC73 →	+0.241	+0.741	<.001	<.001	3	4
BRCA	MCM2_S27 →	+0.620	+0.326	.001	<.001	3	4
HNSC	MCM4 →	+0.484	+0.600	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,266 associations by consensus.

Exploration

HMSD survival (RNA) · tumor vs normal (RNA) · all HMSD data types