HMOX2

Across TCGA pan-cancer cohorts, HMOX2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HMOX2 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HMOX2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HMOX2 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where HMOX2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.920	.014	18	view →
CCRCC	OS	Tertile	All	0.630	1.000	.007	15	view →
PDAC	DFS	Tertile	III,IV	0.604	0.187	.011	13	view →
GBM	DFS	Median	All	0.234	0.492	.001	11	view →
HNSC	OS	Quartile	II,III,IV	0.970	0.807	.014	10	view →
LUAD	OS	Quartile	II,III,IV	0.868	0.498	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HMOX2–COAD (DFS)

Open the COAD breakdown →