HMOX2

Across TCGA patient cohorts, HMOX2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMOX2-associated genes across cancer lineages are ACC1, MEK1, and c-Kit. Each is linked with HMOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMOX2-to-partner and partner-to-HMOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by HMOX2-low versus HMOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMOX2→partner) and Y-score (partner→HMOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.424	+2.321	.020	.035	2	1
UCEC	MEK1 →	+0.466	+3.000	.011	.036	2	1
UCEC	c-Kit →	-0.251	-2.321	.032	.035	2	1
UCEC	ACC_pS79 →	+0.497	+2.321	.004	.035	1	1
UCEC	p62 Lck ligand →	+0.431	+3.459	.008	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ACC1 by HMOX2 expression — UCEC

Explore this box plot interactively →