HMOX2

Across TCGA cell cohorts, HMOX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,984 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HMOX2-associated GO terms across cancer lineages are rRNA pseudouridine synthesis, Negative regulation of autophagosome maturation, and Enzyme-directed rRNA pseudouridine synthesis. Each is linked with HMOX2 in more than 11 cancer types. Because this analysis shows association rather than direction, both HMOX2-to-partner and partner-to-HMOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA pseudouridine synthesis grouped by HMOX2-low versus HMOX2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMOX2→partner) and Y-score (partner→HMOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	rRNA pseudouridine synthesis →	+0.099	+1.035	.003	<.001	3	12
OESOPHAGUS	Negative regulation of autophagosome maturation →	+0.089	+0.976	.002	.003	3	10
LUNG_SCLC	Enzyme-directed rRNA pseudouridine synthesis →	+0.115	+0.559	.002	.005	3	10
BLOOD_Lymphoma	Mitochondrial ribosome assembly →	+0.069	+0.672	<.001	<.001	3	10
URINARY_TRACT	CAMP/PKA signal transduction →	+0.152	+0.780	<.001	<.001	3	9
PANCREAS	Replication-born double-strand break repair via sister chromatid exchange →	-0.091	-0.632	.007	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,984 associations by consensus.

rRNA pseudouridine synthesis by HMOX2 expression — URINARY_TRACT

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