HMOX1

Across TCGA pan-cancer cohorts, HMOX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HMOX1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HMOX1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HMOX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where HMOX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.908	0.786	.007	17	view →
LUAD	OS	Tertile	All	0.366	0.831	.019	11	view →
UCEC	DFS	Median	All	0.780	0.930	.016	8	view →
PDAC	OS	Tertile	III,IV	0.236	0.668	.021	6	view →
GBM	OS	Quartile	All	0.306	0.550	.015	5	view →
LSCC	DFS	Quartile	II,III,IV	0.933	0.729	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HMOX1–HNSC (OS)

Open the HNSC breakdown →