HMOX1

Across TCGA patient cohorts, HMOX1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMOX1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ERK2. Each is linked with HMOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMOX1-to-partner and partner-to-HMOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HMOX1-low versus HMOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMOX1→partner) and Y-score (partner→HMOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.257	-2.700	.015	.006	3	1
UCEC	eIF4E →	+0.185	+3.183	.039	.009	3	1
UCEC	ERK2 →	+0.181	+3.169	.027	.018	3	1
UCEC	INPP4B →	-0.287	-3.321	.036	.009	3	1
UCEC	Ku80 →	+0.216	+1.713	.031	.027	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.448	-3.169	.019	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by HMOX1 expression — UCEC

Explore this box plot interactively →