HMMR

Across TCGA patient cohorts, HMMR protein abundance is significantly associated with the RNA expression of many other genes, with 12,463 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMMR-associated genes across cancer lineages are MYBL2, CDK1, and KPNA2. Each is linked with HMMR in more than 6 cancer types. Because this analysis shows association rather than direction, both HMMR-to-partner and partner-to-HMMR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMMR versus MYBL2 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMMR→partner) and Y-score (partner→HMMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYBL2 →	+1.444	+0.663	<.001	<.001	3	7
OV	CDK1 →	+1.263	+0.884	<.001	<.001	3	7
BRCA	KPNA2 →	+1.109	+0.738	<.001	<.001	3	7
OV	CDKN3 →	+1.714	+0.781	<.001	<.001	3	6
LUAD	FAM83D →	+1.122	+0.784	<.001	<.001	3	6
OV	CENPI →	+1.092	+0.663	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,463 associations by consensus.

HMMR vs MYBL2 — BRCA

Explore this scatter interactively →