HMMR

Across TCGA patient cohorts, HMMR mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMMR-associated genes across cancer lineages are AR, EGFR_pY1068, and EGFR. Each is linked with HMMR in more than 1 cancer types. Because this analysis shows association rather than direction, both HMMR-to-partner and partner-to-HMMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by HMMR-low versus HMMR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMMR→partner) and Y-score (partner→HMMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AR →	-0.289	-1.362	.028	.037	3	2
UCEC	EGFR_pY1068 →	-0.255	-3.700	.003	.001	3	1
UCEC	EGFR →	-0.158	-1.973	.005	.029	3	1
UCEC	eIF4E →	+0.178	+2.392	.016	<.001	3	1
UCEC	eIF4G →	+0.280	+2.321	.010	.033	3	1
UCEC	FoxM1 →	+0.206	+2.000	.024	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

AR by HMMR expression — UCEC

Explore this box plot interactively →