HMMR

Across TCGA cell cohorts, HMMR mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMMR-associated genes across cancer lineages are PRAMEF17, OR2H1, and SPINK8. Each is linked with HMMR in more than 1 cancer types. Because this analysis shows association rather than direction, both HMMR-to-partner and partner-to-HMMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF17 grouped by HMMR-low versus HMMR-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMMR→partner) and Y-score (partner→HMMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRAMEF17 →	+0.012	+5.022	<.001	.002	3	1
SKIN	OR2H1 →	+0.029	+4.273	<.001	.006	3	1
OVARY	SPINK8 →	+0.174	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.029	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	GLT6D1 →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.009	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRAMEF17 by HMMR expression — SKIN

Explore this box plot interactively →