HMHB1

Across TCGA patient cohorts, HMHB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,065 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMHB1-associated GO terms across cancer lineages are Positive regulation of hemopoiesis, Regulation of CD4-positive, alpha-beta T cell activation, and Negative regulation of leukocyte cell-cell adhesion. Each is linked with HMHB1 in more than 17 cancer types. Because this analysis shows association rather than direction, both HMHB1-to-partner and partner-to-HMHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of hemopoiesis grouped by HMHB1-low versus HMHB1-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMHB1→partner) and Y-score (partner→HMHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Positive regulation of hemopoiesis →	+0.078	+0.589	<.001	<.001	3	18
SCLC	Regulation of CD4-positive, alpha-beta T cell activation →	+0.078	+0.506	<.001	<.001	3	18
SCLC	Negative regulation of leukocyte cell-cell adhesion →	+0.076	+0.361	<.001	.002	3	17
SCLC	Lymphocyte homeostasis →	+0.096	+0.632	<.001	<.001	3	17
SCLC	Interleukin-10 production →	+0.097	+0.642	<.001	<.001	3	17
SCLC	Interleukin-2-mediated signaling pathway →	+0.194	+0.605	<.001	<.001	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,065 associations by consensus.

Positive regulation of hemopoiesis by HMHB1 expression — SCLC

Explore this box plot interactively →