HMHB1

Across TCGA cell cohorts, HMHB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,019 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMHB1-associated GO terms across cancer lineages are Macrophage apoptotic process, Wax biosynthetic process, and Wax metabolic process. Each is linked with HMHB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HMHB1-to-partner and partner-to-HMHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophage apoptotic process grouped by HMHB1-low versus HMHB1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMHB1→partner) and Y-score (partner→HMHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Macrophage apoptotic process →	-0.076	-1.669	.002	<.001	3	3
BLOOD_Myeloma	Wax biosynthetic process →	-0.137	-0.119	.004	.005	3	2
BLOOD_Myeloma	Wax metabolic process →	-0.137	-0.119	.004	.005	3	2
BLOOD_Leukemia	Membrane invagination →	-0.097	-1.852	<.001	.001	3	2
BLOOD_Leukemia	Primary neural tube formation →	-0.048	-1.397	<.001	<.001	3	2
BLOOD_Leukemia	Zinc export across plasma membrane →	-0.545	-0.968	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,019 associations by consensus.

Macrophage apoptotic process by HMHB1 expression — BLOOD_Leukemia

Explore this box plot interactively →