HMGXB4

Across TCGA pan-cancer cohorts, HMGXB4 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HMGXB4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where HMGXB4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HMGXB4 is over-expressed in tumor.

LSCC, HNSC, and LUAD are the cancer types where HMGXB4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGXB4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.441	<.001	8	view →
HNSC	Male	III,IV	+0.347	<.001	8	view →
LUAD	Male	All	+0.266	<.001	8	view →
CCRCC	Male	All	+0.156	<.001	6	view →
PDAC	All	II,III,IV	+0.323	.004	4	view →
OV	All	All	+0.365	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HMGXB4–LSCC

Open the LSCC breakdown →