HMGXB3

Across TCGA pan-cancer cohorts, HMGXB3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HMGXB3 data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HMGXB3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HMGXB3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where HMGXB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.909	0.487	.009	8	view →
LSCC	OS	Tertile	All	0.659	0.899	.010	6	view →
HNSC	DFS	Median	All	0.851	0.734	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HMGXB3–CCRCC (DFS)

Open the CCRCC breakdown →