Across TCGA pan-cancer cohorts, HMGN5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HMGN5 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HMGN5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HMGN5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and HNSC are the cancer types where HMGN5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.082	0.871	<.001	48	view →
UCEC	DFS	Median	All	1.000	0.633	.012	30	view →
HNSC	OS	Median	II,III,IV	0.002	0.757	<.001	30	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HMGN5 tumor-vs-normal RNA expression · all HMGN5 data types