Across TCGA patient cohorts, HMGN5 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,334 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HMGN5-associated proteins across cancer lineages are SH3BGRL, HMGN5_S93, and BDH2. Each is linked with HMGN5 in more than 5 cancer types. Because this analysis shows association rather than direction, both HMGN5-to-partner and partner-to-HMGN5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN5→partner) and Y-score (partner→HMGN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH3BGRL →	+0.642	+0.863	<.001	<.001	3	6
LSCC	HMGN5_S93 →	+0.885	+0.526	<.001	<.001	3	5
LSCC	BDH2 →	+0.449	+0.339	<.001	.006	3	4
LUAD	DDX21_S121 →	-0.639	-0.530	.003	<.001	3	4
BRCA	DDAH1 →	+0.461	+0.650	.004	<.001	3	4
CCRCC	LYAR_S260 →	-0.577	-0.344	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,334 associations by consensus.

Exploration

HMGN5 survival (RNA) · tumor vs normal (RNA) · all HMGN5 data types