Across TCGA patient cohorts, HMGN5 protein abundance is significantly associated with the RNA expression of many other genes, with 14,664 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HMGN5-associated genes across cancer lineages are ZNF711, BEX5, and DNAH7. Each is linked with HMGN5 in more than 6 cancer types. Because this analysis shows association rather than direction, both HMGN5-to-partner and partner-to-HMGN5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN5→partner) and Y-score (partner→HMGN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF711 →	+1.071	+0.665	<.001	<.001	3	7
COAD	BEX5 →	+1.583	+0.619	<.001	<.001	3	6
GBM	DNAH7 →	+1.013	+0.554	<.001	<.001	3	6
BRCA	ALDH6A1 →	+1.005	+0.777	<.001	<.001	3	6
BRCA	ZNF540 →	+0.680	+0.505	<.001	<.001	3	6
UCEC	ZBTB20 →	+0.685	+0.618	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,664 associations by consensus.

Exploration

HMGN5 survival (RNA) · tumor vs normal (RNA) · all HMGN5 data types