Across TCGA patient cohorts, HMGN5 mutation is significantly associated with the RNA expression of many other genes, with 2,699 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGN5-associated genes across cancer lineages are RN7SL134P, HMX3, and WBP1LP8. Each is linked with HMGN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGN5-to-partner and partner-to-HMGN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN5→partner) and Y-score (partner→HMGN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.097	+2.014	.001	.003	3	2
UCEC	HMX3 →	+0.544	+1.424	<.001	.008	3	2
BRCA	WBP1LP8 →	+0.063	+7.057	<.001	.009	3	1
HNSC	GSX1 →	+0.779	+4.780	<.001	.003	3	1
HNSC	RNU6-212P →	+0.589	+4.398	<.001	.006	3	1
HNSC	RNA5SP188 →	+0.253	+5.608	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,699 associations by consensus.

Exploration

HMGN5 survival (RNA) · tumor vs normal (RNA) · all HMGN5 data types