Across TCGA patient cohorts, HMGN5 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGN5-associated genes across cancer lineages are CD49b, 14-3-3_beta, and EGFR_pY1068. Each is linked with HMGN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGN5-to-partner and partner-to-HMGN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN5→partner) and Y-score (partner→HMGN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD49b →	-0.321	-2.787	.001	.003	3	2
UCEC	14-3-3_beta →	-0.116	-2.558	.001	.010	3	1
UCEC	EGFR_pY1068 →	-0.264	-1.925	.003	.005	3	1
UCEC	eIF4E →	+0.186	+3.335	.014	.005	3	1
UCEC	A-Raf_pS299 →	-0.118	-1.807	.006	.025	3	1
UCEC	ERK2 →	+0.174	+1.874	.011	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

HMGN5 survival (RNA) · tumor vs normal (RNA) · all HMGN5 data types