HMGN4

Across TCGA pan-cancer cohorts, HMGN4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HMGN4 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HMGN4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HMGN4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where HMGN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	1.000	0.768	.003	29	view →
PDAC	DFS	Quartile	III,IV	0.979	0.386	.004	16	view →
LUAD	DFS	Tertile	II,III,IV	0.610	0.993	.001	13	view →
HNSC	DFS	Quartile	II,III,IV	0.870	0.982	.031	2	view →
LSCC	DFS	Median	III,IV	0.495	0.844	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HMGN4–CCRCC (OS)

Open the CCRCC breakdown →