HMGN4

Across TCGA patient cohorts, HMGN4 protein abundance is significantly associated with the RNA expression of many other genes, with 16,547 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGN4-associated genes across cancer lineages are KPNA2, ANLN, and CEP55. Each is linked with HMGN4 in more than 9 cancer types. Because this analysis shows association rather than direction, both HMGN4-to-partner and partner-to-HMGN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGN4 versus KPNA2 in LUAD, with a Pearson correlation of -0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN4→partner) and Y-score (partner→HMGN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KPNA2 →	-0.916	-0.514	<.001	<.001	3	10
BRCA	ANLN →	-1.484	-0.852	<.001	<.001	3	9
OV	CEP55 →	-1.326	-0.755	<.001	<.001	3	9
OV	CENPE →	-1.206	-0.803	<.001	<.001	3	9
BRCA	SHCBP1 →	-0.978	-0.719	<.001	<.001	3	9
LUAD	CDC6 →	-1.044	-0.575	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,547 associations by consensus.

HMGN4 vs KPNA2 — LUAD

Explore this scatter interactively →