HMGN4

Across TCGA patient cohorts, HMGN4 mutation is significantly associated with the RNA expression of many other genes, with 459 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGN4-associated genes across cancer lineages are CCDC3, AP1S3, and FLCN. Each is linked with HMGN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGN4-to-partner and partner-to-HMGN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC3 grouped by HMGN4-low versus HMGN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN4→partner) and Y-score (partner→HMGN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC3 →	-1.195	-3.700	<.001	.001	3	1
UCEC	AP1S3 →	+0.658	+3.346	.002	.005	3	1
UCEC	FLCN →	+0.462	+3.721	.003	<.001	3	1
UCEC	PI4K2A →	+0.524	+3.700	<.001	.001	3	1
UCEC	ADAMTSL3 →	-0.684	-3.689	.009	.001	3	1
UCEC	SFR1 →	+0.557	+2.595	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 459 associations by consensus.

CCDC3 by HMGN4 expression — UCEC

Explore this box plot interactively →