HMGN4

Across TCGA patient cohorts, HMGN4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGN4-associated genes across cancer lineages are ERK2, JNK2, and Beclin. Each is linked with HMGN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGN4-to-partner and partner-to-HMGN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by HMGN4-low versus HMGN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN4→partner) and Y-score (partner→HMGN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.219	+2.321	.023	.035	3	1
UCEC	JNK2 →	+0.236	+2.817	.018	.036	3	1
UCEC	Beclin →	+0.117	+3.459	.013	.005	3	1
UCEC	PDCD4 →	-0.725	-2.990	.002	.036	2	1
UCEC	Shc_pY317 →	-0.163	-2.321	.033	.035	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ERK2 by HMGN4 expression — UCEC

Explore this box plot interactively →