HMGN4

Across TCGA cell cohorts, HMGN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,099 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMGN4-associated GO terms across cancer lineages are Circadian sleep/wake cycle, Negative regulation of RNA export from nucleus, and DNA synthesis involved in DNA repair. Each is linked with HMGN4 in more than 9 cancer types. Because this analysis shows association rather than direction, both HMGN4-to-partner and partner-to-HMGN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Circadian sleep/wake cycle grouped by HMGN4-low versus HMGN4-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN4→partner) and Y-score (partner→HMGN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Circadian sleep/wake cycle →	+0.101	+0.807	.004	.003	3	10
PANCREAS	Negative regulation of RNA export from nucleus →	+0.140	+1.080	<.001	<.001	3	10
LIVER	DNA synthesis involved in DNA repair →	+0.086	+0.883	<.001	.004	3	10
BREAST	Transport of virus →	+0.197	+1.266	<.001	<.001	3	9
BREAST	Intracellular transport of virus →	+0.197	+1.266	<.001	<.001	3	9
PANCREAS	Protein linear polyubiquitination →	-0.149	-1.084	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,099 associations by consensus.

Circadian sleep/wake cycle by HMGN4 expression — PANCREAS

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