HMGN3

Across TCGA pan-cancer cohorts, HMGN3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HMGN3 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HMGN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGN3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where HMGN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.348	0.822	<.001	31	view →
HNSC	DFS	Median	All	0.316	0.886	.012	26	view →
PDAC	OS	Median	All	0.444	0.631	.002	24	view →
UCEC	DFS	Median	All	0.936	1.000	.022	12	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.578	.012	8	view →
LSCC	DFS	Median	All	0.846	0.729	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HMGN3–LUAD (DFS)

Open the LUAD breakdown →