HMGN3

Across TCGA patient cohorts, HMGN3 protein abundance is significantly associated with the RNA expression of many other genes, with 18,984 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGN3-associated genes across cancer lineages are CXCL1, UBE3D, and PLA2G5. Each is linked with HMGN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both HMGN3-to-partner and partner-to-HMGN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGN3 versus CXCL1 in GBM, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN3→partner) and Y-score (partner→HMGN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CXCL1 →	-1.451	-0.526	<.001	<.001	3	4
GBM	UBE3D →	+0.454	+0.389	<.001	<.001	3	3
GBM	PLA2G5 →	-1.916	-0.558	<.001	<.001	3	3
OV	SURF4 →	-0.432	-0.580	<.001	<.001	3	3
OV	PDPN →	-1.208	-0.728	.001	.002	3	3
BRCA	CAVIN3 →	-0.773	-0.451	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,984 associations by consensus.

HMGN3 vs CXCL1 — GBM

Explore this scatter interactively →