HMGN3

Across TCGA cell cohorts, HMGN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,526 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HMGN3-associated GO terms across cancer lineages are Replication fork processing, DNA-templated DNA replication maintenance of fidelity, and DNA-templated DNA replication. Each is linked with HMGN3 in more than 12 cancer types. Because this analysis shows association rather than direction, both HMGN3-to-partner and partner-to-HMGN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication fork processing grouped by HMGN3-low versus HMGN3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN3→partner) and Y-score (partner→HMGN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Replication fork processing →	+0.111	+1.119	<.001	<.001	3	13
BREAST	DNA-templated DNA replication maintenance of fidelity →	+0.101	+1.366	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.096	+1.409	.003	.006	3	11
BREAST	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.106	+0.921	.002	.004	3	11
BREAST	Negative regulation of chromosome separation →	+0.106	+0.921	.002	.004	3	11
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.085	+0.962	.004	.006	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,526 associations by consensus.

Replication fork processing by HMGN3 expression — SOFT_TISSUE

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