Across TCGA pan-cancer cohorts, HMGN2P7 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HMGN2P7’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where HMGN2P7 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN2P7 is over-expressed in tumor, although a few such as PAAD and THCA show the opposite, repressed pattern.
PAAD, COAD, and THCA are the cancer types where HMGN2P7 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P7 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.