HMGN2P6

Across TCGA pan-cancer cohorts, HMGN2P6 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HMGN2P6 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HMGN2P6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGN2P6 expression acts as an unfavorable survival marker, although some lineages such as THYM and OV show a favorable association.

ACC, THYM, and KICH are the cancer types where HMGN2P6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.249	0.666	<.001	80	view →
THYM	OS	Tertile	All	1.000	0.682	.001	30	view →
KICH	OS	Tertile	III,IV	0.194	0.844	.003	28	view →
LGG	DFS	Tertile	All	0.652	0.800	<.001	28	view →
OV	OS	Tertile	IV	0.972	0.631	.010	18	view →
KIRC	DFS	Quartile	All	0.758	0.466	.004	17	view →
SARC	OS	Median	All	0.374	0.602	.002	17	view →
UVM	DFS	Tertile	III,IV	0.891	0.393	.018	16	view →
BRCA	DFS	Quartile	II,III,IV	0.464	0.646	.020	13	view →
MESO	DFS	Tertile	IV	0.651	0.231	.011	12	view →
SKCM	OS	Tertile	III,IV	0.496	0.286	.009	10	view →
LUSC	OS	Quartile	III,IV	0.104	0.857	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HMGN2P6–ACC (DFS)

Open the ACC breakdown →