HMGN2P46

Across TCGA pan-cancer cohorts, HMGN2P46 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HMGN2P46’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HMGN2P46 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN2P46 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where HMGN2P46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.666	<.001	9	view →
LUAD	All	All	+0.399	<.001	7	view →
BRCA	All	All	+0.340	<.001	6	view →
KICH	All	All	−0.209	<.001	6	view →
LUSC	All	All	−0.182	.006	6	view →
HNSC	Male	III,IV	+0.248	.002	4	view →
THCA	Male	All	−0.181	.009	4	view →
LIHC	All	All	+0.084	<.001	4	view →
CHOL	All	All	+0.560	<.001	3	view →
PRAD	All	All	+1.247	.001	2	view →
UCEC	All	All	−0.266	.006	2	view →
KIRC	Male	All	+0.077	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HMGN2P46–COAD

Open the COAD breakdown →