HMGN2P4

Across TCGA pan-cancer cohorts, HMGN2P4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HMGN2P4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMGN2P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGN2P4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BRCA, and THCA are the cancer types where HMGN2P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.274	.002	6	view →
BRCA	All	II,III,IV	+0.266	<.001	6	view →
THCA	All	All	−0.236	.005	5	view →
LUAD	Male	All	+0.305	.022	4	view →
KIRC	All	All	+0.170	.002	4	view →
LIHC	Male	All	+0.340	<.001	3	view →
CHOL	All	All	+0.874	.004	2	view →
ESCA	All	All	+0.705	.015	2	view →
BLCA	Female	III,IV	+0.641	.017	2	view →
LUSC	All	All	+0.203	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HMGN2P4–HNSC

Open the HNSC breakdown →