HMGN2P3

Across TCGA pan-cancer cohorts, HMGN2P3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of HMGN2P3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HMGN2P3 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN2P3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, BRCA, and HNSC are the cancer types where HMGN2P3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.502	<.001	6	view →
BRCA	All	II,III,IV	+0.463	<.001	6	view →
HNSC	Male	All	+0.420	.006	4	view →
LIHC	Male	All	+0.758	<.001	3	view →
ESCA	Male	All	+0.996	.004	2	view →
THCA	All	All	−0.403	.005	2	view →
STAD	All	II,III,IV	+0.564	.042	1	view →
KIRC	Male	All	+0.288	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

HMGN2P3–KICH

Open the KICH breakdown →