Across TCGA pan-cancer cohorts, HMGN2P25 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HMGN2P25’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HMGN2P25 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN2P25 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, STAD, and CHOL are the cancer types where HMGN2P25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.436	.001	5	view →
STAD	All	II,III,IV	+0.210	.009	5	view →
CHOL	All	All	+0.213	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HMGN2P25 RNA expression & survival · all HMGN2P25 data types