Across TCGA pan-cancer cohorts, HMGN2P21 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HMGN2P21’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where HMGN2P21 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN2P21 is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

BRCA and COAD are the cancer types where HMGN2P21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	IV	−0.180	.019	2	view →
COAD	Female	IV	−0.395	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: HMGN2P21 RNA expression & survival · all HMGN2P21 data types