HMGN2P17

Across TCGA pan-cancer cohorts, HMGN2P17 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HMGN2P17’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HMGN2P17 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN2P17 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and BRCA are the cancer types where HMGN2P17 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P17 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.442	<.001	9	view →
COAD	Female	All	−1.031	<.001	6	view →
BRCA	All	III,IV	+0.709	<.001	6	view →
HNSC	All	All	+0.338	.005	5	view →
STAD	Male	II,III,IV	+0.227	.011	4	view →
LIHC	Male	All	+0.486	.009	3	view →
CHOL	All	All	+0.830	.014	2	view →
THCA	All	All	−0.260	.023	2	view →
KIRC	All	All	+0.248	.008	2	view →
BLCA	Female	III,IV	+0.451	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HMGN2P17–KICH

Open the KICH breakdown →