Across TCGA patient cohorts, HMGN2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,431 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMGN2-associated genes across cancer lineages are KIAA0930, LINC00339, and TYMP. Each is linked with HMGN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HMGN2-to-partner and partner-to-HMGN2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN2→partner) and Y-score (partner→HMGN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIAA0930 →	-0.513	-0.279	.003	.003	3	4
BRCA	LINC00339 →	+0.368	+0.815	<.001	<.001	3	4
OV	TYMP →	-0.888	-0.581	<.001	<.001	3	4
BRCA	USP48 →	+0.397	+0.836	<.001	<.001	3	4
OV	DST →	-1.249	-0.806	<.001	<.001	3	4
OV	RUNX1 →	-0.832	-0.599	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,431 associations by consensus.

Exploration

HMGN2 survival (RNA) · tumor vs normal (RNA) · all HMGN2 data types