Across TCGA pan-cancer cohorts, HMGN1P4 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HMGN1P4’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where HMGN1P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGN1P4 is over-expressed in tumor.
BRCA, LUAD, and BLCA are the cancer types where HMGN1P4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN1P4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.