Across TCGA pan-cancer cohorts, HMGN1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HMGN1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HMGN1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HMGN1 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, PDAC, and COAD are the cancer types where HMGN1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.572	<.001	9	view →
PDAC	All	III,IV	−0.548	<.001	9	view →
COAD	Male	III,IV	+0.436	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HMGN1 RNA expression & survival · all HMGN1 data types