Across TCGA patient cohorts, HMGN1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,956 significant associations in total. OV shows the largest number of these associations.

The most reproducible HMGN1-associated genes across cancer lineages are BRWD1, DYRK1A, and METTL21AP1. Each is linked with HMGN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HMGN1-to-partner and partner-to-HMGN1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN1→partner) and Y-score (partner→HMGN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BRWD1 →	+0.660	+0.622	<.001	<.001	3	5
HNSC	DYRK1A →	+0.376	+0.327	<.001	.001	3	4
HNSC	METTL21AP1 →	+0.488	+0.327	.003	.004	3	4
GBM	TREM1 →	-1.765	-0.443	<.001	<.001	3	4
GBM	SPOCD1 →	-1.132	-0.291	.002	.004	3	4
GBM	SLC11A1 →	-1.577	-0.442	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,956 associations by consensus.

Exploration

HMGN1 survival (RNA) · tumor vs normal (RNA) · all HMGN1 data types