Across TCGA patient cohorts, HMGN1 mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGN1-associated genes across cancer lineages are NUTF2, TBC1D13, and GRPEL1. Each is linked with HMGN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGN1-to-partner and partner-to-HMGN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN1→partner) and Y-score (partner→HMGN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUTF2 →	+0.570	+3.201	<.001	.009	3	1
UCEC	TBC1D13 →	+0.528	+3.459	.001	.005	3	1
UCEC	GRPEL1 →	+0.502	+3.202	.003	.009	3	1
UCEC	CYP27B1 →	+0.730	+3.491	<.001	.002	3	1
UCEC	DAP →	+0.596	+3.491	.003	.002	3	1
UCEC	ABCB6 →	+0.656	+3.470	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

Exploration

HMGN1 survival (RNA) · tumor vs normal (RNA) · all HMGN1 data types