Across TCGA patient cohorts, HMGN1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGN1-associated genes across cancer lineages are Ku80, p62 Lck ligand, and Rab25. Each is linked with HMGN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGN1-to-partner and partner-to-HMGN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGN1→partner) and Y-score (partner→HMGN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.320	+3.335	.009	.005	3	1
UCEC	p62 Lck ligand →	+0.537	+3.009	.001	.019	3	1
UCEC	Rab25 →	-0.441	-3.000	.011	.036	3	1
UCEC	STAT3_pY705 →	-0.489	-3.321	<.001	.010	3	1
UCEC	Tuberin →	+0.515	+2.817	<.001	.036	3	1
UCEC	VHL →	-1.587	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HMGN1 survival (RNA) · tumor vs normal (RNA) · all HMGN1 data types