HMGCS2

Across TCGA patient cohorts, HMGCS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,499 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HMGCS2-associated proteins across cancer lineages are COLGALT1, NOSTRIN, and CPT2. Each is linked with HMGCS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HMGCS2-to-partner and partner-to-HMGCS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGCS2 versus COLGALT1 in BRCA, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS2→partner) and Y-score (partner→HMGCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COLGALT1 →	-0.401	-2.429	<.001	<.001	3	6
BRCA	NOSTRIN →	+0.922	+2.668	<.001	<.001	3	6
PDAC	CPT2 →	+0.363	+2.632	<.001	<.001	3	5
BRCA	HID1 →	+0.765	+1.833	<.001	<.001	3	5
BRCA	GPD1L →	+0.648	+2.710	<.001	<.001	3	5
CCRCC	TPPP3 →	+0.641	+1.943	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,499 associations by consensus.

HMGCS2 vs COLGALT1 — BRCA

Explore this scatter interactively →