HMGCS2

Across TCGA patient cohorts, HMGCS2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,622 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HMGCS2-associated genes across cancer lineages are SELENBP1, NDRG2, and FAM3D. Each is linked with HMGCS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HMGCS2-to-partner and partner-to-HMGCS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGCS2 versus SELENBP1 in PDAC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS2→partner) and Y-score (partner→HMGCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SELENBP1 →	+1.057	+1.545	<.001	<.001	3	4
UCEC	NDRG2 →	+1.007	+1.265	.001	.002	3	4
PDAC	FAM3D →	+1.654	+1.105	<.001	.009	3	4
PDAC	LRRC31 →	+1.554	+1.521	<.001	<.001	3	4
HNSC	ODAM →	+1.412	+0.533	.001	.003	3	3
GBM	CNTFR →	+2.026	+0.895	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,622 associations by consensus.

HMGCS2 vs SELENBP1 — PDAC

Explore this scatter interactively →