HMGCS2

Across TCGA cell cohorts, HMGCS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,431 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMGCS2-associated GO terms across cancer lineages are Lateral line system development, Fatty acid beta-oxidation, and Regulation of extrinsic apoptotic signaling pathway. Each is linked with HMGCS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HMGCS2-to-partner and partner-to-HMGCS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lateral line system development grouped by HMGCS2-low versus HMGCS2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS2→partner) and Y-score (partner→HMGCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Lateral line system development →	+1.451	+2.552	<.001	.003	3	6
LARGE_INTESTINE	Fatty acid beta-oxidation →	+0.080	+3.130	<.001	<.001	3	6
LARGE_INTESTINE	Regulation of extrinsic apoptotic signaling pathway →	-0.045	-2.265	<.001	<.001	3	5
STOMACH	Secretion by tissue →	+0.367	+3.469	.001	.001	3	5
LARGE_INTESTINE	Monoacylglycerol metabolic process →	+0.133	+3.012	<.001	.003	3	5
LARGE_INTESTINE	Isopentenyl diphosphate metabolic process →	+0.099	+2.664	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,431 associations by consensus.

Lateral line system development by HMGCS2 expression — STOMACH

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