HMGCS2

Across TCGA cell cohorts, HMGCS2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMGCS2-associated genes across cancer lineages are C6orf118, SCN2A, and COX6A2. Each is linked with HMGCS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCS2-to-partner and partner-to-HMGCS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by HMGCS2-low versus HMGCS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS2→partner) and Y-score (partner→HMGCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.085	+3.115	.008	.004	3	1
LARGE_INTESTINE	SCN2A →	+0.520	+3.658	<.001	.003	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.243	+2.925	.007	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SPINK6 →	+0.782	+2.936	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C6orf118 by HMGCS2 expression — LARGE_INTESTINE

Explore this box plot interactively →