HMGCLL1

Across TCGA cell cohorts, HMGCLL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,175 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible HMGCLL1-associated GO terms across cancer lineages are Translational initiation, Cytoplasmic translation, and Aerobic electron transport chain. Each is linked with HMGCLL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HMGCLL1-to-partner and partner-to-HMGCLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Translational initiation grouped by HMGCLL1-low versus HMGCLL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCLL1→partner) and Y-score (partner→HMGCLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Translational initiation →	+0.068	+1.105	<.001	.002	3	10
OESOPHAGUS	Cytoplasmic translation →	+0.122	+0.538	<.001	<.001	3	9
OESOPHAGUS	Aerobic electron transport chain →	+0.119	+0.511	.001	.002	3	8
OESOPHAGUS	ATP synthesis coupled electron transport →	+0.099	+0.385	<.001	.002	3	8
OESOPHAGUS	Mitochondrial ATP synthesis coupled electron transport →	+0.099	+0.385	<.001	.002	3	8
OESOPHAGUS	ATP biosynthetic process →	+0.129	+0.441	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,175 associations by consensus.

Translational initiation by HMGCLL1 expression — LUNG_SCLC

Explore this box plot interactively →