HMGCLL1

Across TCGA cell cohorts, HMGCLL1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMGCLL1-associated genes across cancer lineages are TMSB4Y, ADH1B, and ZCWPW2. Each is linked with HMGCLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCLL1-to-partner and partner-to-HMGCLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMSB4Y grouped by HMGCLL1-low versus HMGCLL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCLL1→partner) and Y-score (partner→HMGCLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMSB4Y →	+1.066	+3.374	.002	.005	3	1
LARGE_INTESTINE	ADH1B →	+0.040	+2.989	.007	.003	3	1
LARGE_INTESTINE	ZCWPW2 →	+0.200	+3.285	.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TMSB4Y by HMGCLL1 expression — LARGE_INTESTINE

Explore this box plot interactively →