Across TCGA pan-cancer cohorts, HMGB3P8 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated HMGB3P8 data layer.
The strongest signal is observed in uveal melanoma (UVM), where higher HMGB3P8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HMGB3P8 expression acts as an unfavorable survival marker, although some lineages such as ACC and LUAD show a favorable association.
UVM, HNSC, and LIHC are the cancer types where HMGB3P8 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.