Across TCGA pan-cancer cohorts, HMGB3P4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HMGB3P4 data layer.
The strongest signal is observed in kidney chromophobe (KICH), where higher HMGB3P4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB3P4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.
KICH, THCA, and KIRP are the cancer types where HMGB3P4 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.