HMGB3P32

Across TCGA pan-cancer cohorts, HMGB3P32 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of HMGB3P32’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HMGB3P32 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB3P32 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, HNSC, and STAD are the cancer types where HMGB3P32 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB3P32 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.402	<.001	10	view →
HNSC	All	All	+0.122	.002	10	view →
STAD	All	II,III,IV	+0.509	.002	6	view →
COAD	All	II,III,IV	+0.336	<.001	6	view →
LIHC	All	All	+0.116	.005	4	view →
LUSC	Male	III,IV	−0.577	.029	2	view →
THCA	Male	IV	+0.136	.009	2	view →
KICH	Female	III,IV	+0.136	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

HMGB3P32–KIRC

Open the KIRC breakdown →